The Role of Innate Immunity in Autoimmunity

Role of miR-146a in Immune System and Autoimmunity

MicroRNAs (miRNAs) are small preserved non-coding RNA molecules that regulate gene expression post-transcriptionally by targeting the 3' UTR of mRNAs for translational repression or degradation. The rising evidence has established the significant role of miRNAs within the regulation of immune system and the prevention of autoimmunity. MiR-146a has obtained an importance as a modulator of differ...

The Role of Zataria Multiflora Essence (Iranian herb) on Innate Immunity of Animal Model

Background: Herbal medicines have been used since ancient times for treatment of a range of diseases and have represented stimulatory effects on the function of innate immunity. Objective: To evaluate the effects of Zataria multiflora (Z. multiflora) on the function of innate immunity including phagocytic activity and TNF-α secretion in animal model. Methods: Eight BALB/c mice were divided int...

Innate Immunity Plays a Key Role in Leishmania Infection: Implications for Vaccine Design

Neutrophils are part of the first line of immune response and are essential for resistance against a variety of pathogens. They professionally mediate direct killing of pathogens, recruit other phagocytes by specific chemokines, produce cytokines and interact with different immune cells to shape the adaptive response. Leishmania as an obligatory intracellular parasite has evolved to benefit thi...

Possible Role of Autoimmunity in Patients with Premature Ovarian Insuf f iciency

Epidermal mucus, a major determinant in fish health: a review

Fish epidermal mucus contains innate immune components, secreted by globlet cells that provide the primary defence against different pathogenic microbes and act as a barrier between fish and its immediate niche. The major function of mucus includes entrapment and sloughing of microbes. The mucus also contains many factors such as antimicrobial peptides (AMPs), lysozymes, lectins, proteases, etc...